Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cited1tm1Dunw
Name:	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1; targeted mutation 1, Sally L Dunwoodie
MGI ID:	MGI:3028946
Synonyms:	Cited1neo
Gene:	Cited1  Location: ChrX:101290987-101295787 bp, - strand  Genetic Position: ChrX, 45.25 cM
Alliance:	Cited1tm1Dunw page

Germline Transmission:	Earliest citation of germline transmission: J:87595
Parent Cell Line:	E14.2 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region was deleted via cre-mediated recombination of the loxP sites inserted by homologous recombination. Although the targeting vector included an frt-flanked neo cassette and sequence encoding GFP, GFP expression was undetected. Sequence analysis of the targeted locus identified a single base insertion, resulting in a frameshift mutation in the inserted sequence. (J:87595)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Cited1tm1Dunw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cited1 Mutation:	5 strains or lines available

Original:	J:87595 Rodriguez TA, et al., Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol. 2004 Jan;24(1):228-44
All:	5 reference(s)