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Elk1tm1Nor
Targeted Allele Detail
Summary
Symbol: Elk1tm1Nor
Name: ELK1, member of ETS oncogene family; targeted mutation 1, Alfred Nordheim
MGI ID: MGI:3028871
Synonyms: Elk-1-, Elk-1(137)
Gene: Elk1  Location: ChrX:20799634-20816847 bp, - strand  Genetic Position: ChrX, 16.45 cM, cytoband A1-A3
Alliance: Elk1tm1Nor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87597
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, RMCE-ready)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region was replaced with a hygromycin-thymidine kinase cassette which was flanked by non-identical FRT recognition sites. Absence of mRNA transcripts was confirmed by RT-PCR while protein specific assays confirmed that no protein product was present. (J:87597)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elk1 Mutation:  8 strains or lines available
References
Original:  J:87597 Cesari F, et al., Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation. Mol Cell Biol. 2004 Jan;24(1):294-305
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory