Dsc1tm1Pko
Targeted Allele Detail
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| Symbol: |
Dsc1tm1Pko |
| Name: |
desmocollin 1; targeted mutation 1, Peter J Koch |
| MGI ID: |
MGI:3028701 |
| Synonyms: |
dsc1-deltaE17LoxP, dsc1deltaE17LoxP |
| Gene: |
Dsc1 Location: Chr18:20217241-20247928 bp, - strand Genetic Position: Chr18, 11.17 cM
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| Alliance: |
Dsc1tm1Pko page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:87593
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| Parent Cell Line: |
AB2.2 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: Intron 16 and exon 17 were deleted and the 3' end of exon 16 was fused to the 3' UTR. A floxed PGK-neomycin cassette was also inserted 0.23kb downstrean of exon 16. The neomycin cassette was subsequently excised by transient transfection of properly targeted ES cells with a Cre expression plasmid. RT-PCR analysis indicated that an aberrant mRNA was produced which retained intron 15. A truncated protein product is expected rather than gene disruption.
(J:87593)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Dsc1 Mutation: |
48 strains or lines available
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| Original: |
J:87593 Cheng X, et al., Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol Cell Biol. 2004 Jan;24(1):154-63 |
| All: |
1 reference(s) |
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Analysis Tools
