Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Vnn1tm1Pna
Name:	vanin 1; targeted mutation 1, Philippe Naquet
MGI ID:	MGI:3027932
Synonyms:	V1-, Vanin-1 -
Gene:	Vnn1  Location: Chr10:23770586-23781241 bp, + strand  Genetic Position: Chr10, 11.33 cM, cytoband A1-B2
Alliance:	Vnn1tm1Pna page

Germline Transmission:	Earliest citation of germline transmission: J:65449
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a PGK neomycin cassette in reverse orientation. Northern blot analysis of mRNA from kidney and RT-PCR confirmed the absence of transcript while Western blot analysis and immunohistochemistry demonstrated the absence of protein. (J:65449)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vnn1 Mutation:	38 strains or lines available

Original:	J:65449 Pitari G, et al., Pantetheinase activity of membrane-bound vanin-1: lack of free cysteamine in tissues of vanin-1 deficient mice. FEBS Lett. 2000 Oct 20;483(2-3):149-54
All:	14 reference(s)