Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prg2tm1Nal
Name:	proteoglycan 2, bone marrow; targeted mutation 1, Nancy A Lee
MGI ID:	MGI:3027719
Synonyms:	MBP-, mMBP-1-
Gene:	Prg2  Location: Chr2:84810805-84813976 bp, + strand  Genetic Position: Chr2, 49.45 cM
Alliance:	Prg2tm1Nal page

Germline Transmission:	Earliest citation of germline transmission: J:65655
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2, 3, and 4 were replaced with a PGK-neomycin cassette. The replaced sequence includes sequences encoding the signal sequence, propolypeptide, and N-terminal 54 amino acids. RT-PCR demonstrated the absence of transcript. (J:65655)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prg2 Mutation:	19 strains or lines available

Original:	J:65655 Denzler KL, et al., Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. J Immunol. 2000 Nov 15;165(10):5509-17
All:	12 reference(s)