Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cables1tm1Lrz
Name:	CDK5 and Abl enzyme substrate 1; targeted mutation 1, Lawrence R Zukerberg
MGI ID:	MGI:3027499
Synonyms:	Cables-, Cables1tm1Brue
Gene:	Cables1  Location: Chr18:11972600-12078681 bp, + strand  Genetic Position: Chr18, 5.88 cM, cytoband A2
Alliance:	Cables1tm1Lrz page

Germline Transmission:	Earliest citation of germline transmission: J:87478
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.7 kb sequence fragment, encompassing all of exon 1, was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included the start codon, 617 bp of 5' untranslated sequence, and the splice donor site of intron 1. Protein was undetected in homozygous mutant mice by Western blot analysis of endometrial tissue. (J:87478)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Cables1tm1Lrz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cables1 Mutation:	39 strains or lines available

Original:	J:87478 Zukerberg LR, et al., Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res. 2004 Jan 1;64(1):202-8
All:	4 reference(s)