Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Htr4tm1Comp
Name:	5 hydroxytryptamine (serotonin) receptor 4; targeted mutation 1, Valerie Compan
MGI ID:	MGI:3027491
Gene:	Htr4  Location: Chr18:62457275-62629648 bp, + strand  Genetic Position: Chr18, 35.1 cM, cytoband D3
Alliance:	Htr4tm1Comp page

Germline Transmission:	Earliest citation of germline transmission: J:87451
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon encoding the third transmembrane domain was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Autoradiography of frontal brain sections indicated an absence of functional protein in homozygous mutant brain tissue. (J:87451)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr4 Mutation:	31 strains or lines available

Original:	J:87451 Compan V, et al., Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci. 2004 Jan 14;24(2):412-9
All:	13 reference(s)