Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgamtm1Rws
Name:	integrin alpha M; targeted mutation 1, Richard W Stokes
MGI ID:	MGI:3027319
Synonyms:	CD11b-
Gene:	Itgam  Location: Chr7:127661812-127717663 bp, + strand  Genetic Position: Chr7, 69.93 cM, cytoband F4
Alliance:	Itgamtm1Rws page

Germline Transmission:	Earliest citation of germline transmission: J:65847
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 3' and 5' portions of exons 13 and 14, respectively, were replaced with a neomycin selection cassette inserted by homologous recombination. The insertion was expected to preclude the translation of the C-terminal, which includes the majority of the metal-binding domain and the transmembrane domain. (J:65847)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgam Mutation:	47 strains or lines available

Original:	J:65847 Melo MD, et al., Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of mycobacterium tuberculosis in macrophages. Cell Immunol. 2000 Oct 10;205(1):13-23
All:	3 reference(s)