About   Help   FAQ
Ano8 Gene Detail
Summary
  • Symbol
    Ano8
  • Name
    anoctamin 8
  • Synonyms
    Tmem16h
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687327
    NCBI Gene: 382014
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71928663-71938607 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687327
 protein coding gene Chr8:71928660-71938735 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033748
 protein coding gene Chr8:71871450-71883241 (-)
A/J MGP_AJ_G0033731
 protein coding gene Chr8:68947172-68957217 (-)
AKR/J MGP_AKRJ_G0033656
 protein coding gene Chr8:70978907-70988979 (-)
BALB/cJ MGP_BALBcJ_G0033727
 protein coding gene Chr8:69118402-69128286 (-)
C3H/HeJ MGP_C3HHeJ_G0033437
 protein coding gene Chr8:71558551-71569768 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034245
 protein coding gene Chr8:74614900-74624718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031187
 protein coding gene Chr8:63587540-63597409 (-)
CAST/EiJ MGP_CASTEiJ_G0032762
 protein coding gene Chr8:71023052-71033106 (-)
CBA/J MGP_CBAJ_G0033415
 protein coding gene Chr8:77252730-77267116 (-)
DBA/2J MGP_DBA2J_G0033569
 protein coding gene Chr8:68678122-68688233 (-)
FVB/NJ MGP_FVBNJ_G0033511
 protein coding gene Chr8:67757239-67768130 (-)
LP/J MGP_LPJ_G0033656
 protein coding gene Chr8:71848979-71859908 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033558
 protein coding gene Chr8:79807749-79819134 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034262
 protein coding gene Chr8:71043444-71053391 (-)
PWK/PhJ MGP_PWKPhJ_G0032469
 protein coding gene Chr8:67953263-67963640 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032306
 protein coding gene Chr8:69990410-70000453 (-)
WSB/EiJ MGP_WSBEiJ_G0032877
 protein coding gene Chr8:71391667-71403036 (-)



Homology
more
  • Human Ortholog
    ANO8, anoctamin 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANO8, anoctamin 8
  • Synonyms
    KIAA1623, TMEM16H
  • Links
    NCBI Gene ID: 57719
    neXtProt AC: NX_Q9HCE9
    UniProt: Q9HCE9

  • Chr Location
    19p13.11; chr19:17323223-17334855 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    59
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034863 Ensembl Gene Model | MGI Sequence Detail 9945 C57BL/6J ±  kb
transcript ENSMUST00000213382 Ensembl | MGI Sequence Detail 3785 Not Applicable  
polypeptide ENSMUSP00000149365 Ensembl | MGI Sequence Detail 1104 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:198369 Suzuki J, et al., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013 May 10;288(19):13305-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory