Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ptprotm1Wig Name: protein tyrosine phosphatase receptor type O; targeted mutation 1, Roger C Wiggins MGI ID: MGI:2687220 Synonyms: GLEPP1 knockout, Ptpro- Gene: Ptpro  Location: Chr6:137229317-137440231 bp, + strand  Genetic Position: Chr6, 66.75 cM Alliance: Ptprotm1Wig page

Glomeruli podocyte abnormalities in Ptprotm1Wig/Ptprotm1Wig mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:65903
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot and immunofluorescence analyses of homozygous mutant mice, however a polypeptide larger than that produced by the endogenous locus was detected at levels less than 1.2% those of wild-type. (J:65903)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpro Mutation:	122 strains or lines available

Original:	J:65903 Wharram BL, et al., Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest. 2000 Nov;106(10):1281-90
All:	9 reference(s)