About   Help   FAQ
Slc22a14 Gene Detail
Summary
  • Symbol
    Slc22a14
  • Name
    solute carrier family 22 (organic cation transporter), member 14
  • Synonyms
    LOC382113
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685974
    NCBI Gene: 382113
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:118998523-119019473 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685974
 protein coding gene Chr9:118998521-119019496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035414
 protein coding gene Chr9:121893903-122134184 (-)
A/J MGP_AJ_G0035394
 protein coding gene Chr9:117386834-117585465 (-)
AKR/J MGP_AKRJ_G0035327
 protein coding gene Chr9:120438423-120653674 (-)
BALB/cJ MGP_BALBcJ_G0035390
 protein coding gene Chr9:117258000-117462492 (-)
C3H/HeJ MGP_C3HHeJ_G0035098
 protein coding gene Chr9:120898144-121117930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035913
 protein coding gene Chr9:125245488-125467588 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032795
 protein coding gene Chr9:114578936-114784415 (-)
CAST/EiJ MGP_CASTEiJ_G0034402
 protein coding gene Chr9:120862377-121096011 (-)
CBA/J MGP_CBAJ_G0035065
 protein coding gene Chr9:129943125-130174093 (-)
DBA/2J MGP_DBA2J_G0035224
 protein coding gene Chr9:116824397-117029483 (-)
FVB/NJ MGP_FVBNJ_G0035171
 protein coding gene Chr9:115673069-115882949 (-)
LP/J MGP_LPJ_G0035303
 protein coding gene Chr9:122241054-122479261 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035212
 protein coding gene Chr9:130926292-131147859 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035932
 protein coding gene Chr9:120817664-121037383 (-)
PWK/PhJ MGP_PWKPhJ_G0034108
 protein coding gene Chr9:117238438-117454935 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033943
 protein coding gene Chr9:120934771-121142128 (-)
WSB/EiJ MGP_WSBEiJ_G0034523
 protein coding gene Chr9:120705732-120923775 (-)



Homology
more
  • Human Ortholog
    SLC22A14, solute carrier family 22 member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A14, solute carrier family 22 member 14
  • Synonyms
    OCTL2, OCTL4, ORCTL4
  • Links
    NCBI Gene ID: 9389
    neXtProt AC: NX_Q9Y267
    UniProt: Q9Y267

  • Chr Location
    3p22.2; chr3:38278832-38318575 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show severe male infertility, asthenozoospermia, impaired sperm capacitation with intracellular pH dysregulation, decreased in vitro fertilization, abnormal sperm flagellar bending caused by osmotic cell swelling, and structural defects in the annulus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070280 Ensembl Gene Model | MGI Sequence Detail 20951 C57BL/6J ±  kb
    transcript ENSMUST00000093775 Ensembl | MGI Sequence Detail 2213 Not Applicable  
    polypeptide ENSMUSP00000091289 Ensembl | MGI Sequence Detail 629 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
    • Latest
      J:322731 Ito M, et al., Dysregulation of intracellular pH is a cause of impaired capacitation in Slc22a14-deficient mice. Reproduction. 2021 Dec 13;163(1):23-32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory