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Xkr8 Gene Detail
Summary
  • Symbol
    Xkr8
  • Name
    X-linked Kx blood group related 8
  • Synonyms
    4931440N07Rik, LOC381560
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685877
    NCBI Gene: 381560
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132452208-132459857 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685877
 protein coding gene Chr4:132452208-132459916 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028877
 protein coding gene Chr4:134908352-134916180 (-)
A/J MGP_AJ_G0028836
 protein coding gene Chr4:129289903-129297802 (-)
AKR/J MGP_AKRJ_G0028789
 protein coding gene Chr4:132932851-132942707 (-)
BALB/cJ MGP_BALBcJ_G0028859
 protein coding gene Chr4:129908130-129916324 (-)
C3H/HeJ MGP_C3HHeJ_G0028573
 protein coding gene Chr4:133195489-133204121 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029301
 protein coding gene Chr4:139779386-139787312 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026572
 protein coding gene Chr4:122364964-122373352 (-)
CAST/EiJ MGP_CASTEiJ_G0028006
 protein coding gene Chr4:131262245-131269918 (-)
CBA/J MGP_CBAJ_G0028539
 protein coding gene Chr4:143358208-143366078 (-)
DBA/2J MGP_DBA2J_G0028688
 protein coding gene Chr4:129708990-129716595 (-)
FVB/NJ MGP_FVBNJ_G0028655
 protein coding gene Chr4:128568571-128577209 (-)
LP/J MGP_LPJ_G0028789
 protein coding gene Chr4:135056914-135065168 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028681
 protein coding gene Chr4:147950924-147958777 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029339
 protein coding gene Chr4:133352385-133360995 (-)
PWK/PhJ MGP_PWKPhJ_G0027727
 protein coding gene Chr4:126405856-126413830 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027553
 protein coding gene Chr4:129193841-129201444 (-)
WSB/EiJ MGP_WSBEiJ_G0028086
 protein coding gene Chr4:133518726-133528199 (-)



Homology
more
  • Human Ortholog
    XKR8, XK related 8
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XKR8, XK related 8
  • Synonyms
    hXkr8, XRG8
  • Links
    NCBI Gene ID: 55113
    neXtProt AC: NX_Q9H6D3
    UniProt: Q9H6D3

  • Chr Location
    1p35.3; chr1:27959588-27968093 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased testis weight, oligozoospermia, abnormal seminiferous tubule and cauda epididymis morphology, large vacuoles in Sertoli cells, and male infertility caused by inefficient apoptotic testicular germ cell clearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037752 Ensembl Gene Model | MGI Sequence Detail 7650 C57BL/6J ±  kb
    transcript ENSMUST00000045550 Ensembl | MGI Sequence Detail 4245 Not Applicable  
    polypeptide ENSMUSP00000041205 Ensembl | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3035048
    References
    more
    • Summaries
      All 40
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:344898 Chen K, et al., A dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy. J Transl Med. 2023 Apr 26;21(1):279
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory