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Frem3 Gene Detail
Summary
  • Symbol
    Frem3
  • Name
    Fras1 related extracellular matrix protein 3
  • Synonyms
    LOC333315
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685641
    NCBI Gene: 333315
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:81337709-81421985 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 38.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    402 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685641
 protein coding gene Chr8:81337668-81422186 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033818
 protein coding gene Chr8:81340510-81418509 (+)
A/J MGP_AJ_G0033800
 protein coding gene Chr8:78098157-78175221 (+)
AKR/J MGP_AKRJ_G0033727
 protein coding gene Chr8:80444710-80526390 (+)
BALB/cJ MGP_BALBcJ_G0033794
 protein coding gene Chr8:78209242-78290147 (+)
C3H/HeJ MGP_C3HHeJ_G0033503
 protein coding gene Chr8:81071730-81156930 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034314
 protein coding gene Chr8:84465825-84561304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031255
 protein coding gene Chr8:72114681-72188748 (+)
CAST/EiJ MGP_CASTEiJ_G0032834
 protein coding gene Chr8:80411636-80481269 (+)
CBA/J MGP_CBAJ_G0033482
 protein coding gene Chr8:87456544-87549653 (+)
DBA/2J MGP_DBA2J_G0033635
 protein coding gene Chr8:77790020-77862732 (+)
FVB/NJ MGP_FVBNJ_G0033580
 protein coding gene Chr8:76732317-76816874 (+)
LP/J MGP_LPJ_G0033725
 protein coding gene Chr8:81434446-81507715 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033623
 protein coding gene Chr8:89950062-90028281 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034331
 protein coding gene Chr8:80449184-80527431 (+)
PWK/PhJ MGP_PWKPhJ_G0032537
 protein coding gene Chr8:77047418-77119337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032375
 protein coding gene Chr8:79259088-79337892 (+)
WSB/EiJ MGP_WSBEiJ_G0032947
 protein coding gene Chr8:80797260-80883135 (+)



Homology
more
  • Human Ortholog
    FREM3, FRAS1 related extracellular matrix 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FREM3, FRAS1 related extracellular matrix 3
  • Links
    NCBI Gene ID: 166752
    neXtProt AC: NX_P0C091
    UniProt: P0C091

  • Chr Location
    4q31.21; chr4:143577302-143700675 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit no embryonic lethality and normal fertility, size, and no apparent Fraser syndrome- or MOTA/BNAR-like developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    78
  • cDNA Data
    1
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042353 Ensembl Gene Model | MGI Sequence Detail 84277 C57BL/6J ±  kb
transcript ENSMUST00000039695 Ensembl | MGI Sequence Detail 6384 Not Applicable  
polypeptide ENSMUSP00000038015 Ensembl | MGI Sequence Detail 2127 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 1
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 56
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 35
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:291067 Kiyozumi D, et al., Genetic mutation of Frem3 does not causeFraser syndrome in mice. Exp Anim. 2020 Jan 29;69(1):104-109
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory