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Drc7 Gene Detail
Summary
  • Symbol
    Drc7
  • Name
    dynein regulatory complex subunit 7
  • Synonyms
    Ccdc135, LOC330830, SRG-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685616
    NCBI Gene: 330830
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95781731-95804769 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685616
 protein coding gene Chr8:95781731-95804769 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033978
 protein coding gene Chr8:96511049-96535520 (+)
A/J MGP_AJ_G0033961
 protein coding gene Chr8:92749298-92774343 (+)
AKR/J MGP_AKRJ_G0033887
 protein coding gene Chr8:95275333-95298153 (+)
BALB/cJ MGP_BALBcJ_G0033953
 protein coding gene Chr8:92828117-92850957 (+)
C3H/HeJ MGP_C3HHeJ_G0033663
 protein coding gene Chr8:95992115-96017239 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034474
 protein coding gene Chr8:100022257-100046003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031415
 protein coding gene Chr8:86547070-86570280 (+)
CAST/EiJ MGP_CASTEiJ_G0032995
 protein coding gene Chr8:95594423-95619553 (+)
CBA/J MGP_CBAJ_G0033639
 protein coding gene Chr8:103337372-103360327 (+)
DBA/2J MGP_DBA2J_G0033793
 protein coding gene Chr8:92232822-92257358 (+)
FVB/NJ MGP_FVBNJ_G0033740
 protein coding gene Chr8:91178412-91202381 (+)
LP/J MGP_LPJ_G0033885
 protein coding gene Chr8:96651556-96676846 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033782
 protein coding gene Chr8:105609296-105632752 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034492
 protein coding gene Chr8:95437244-95463418 (+)
PWK/PhJ MGP_PWKPhJ_G0032697
 protein coding gene Chr8:91597261-91620350 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032534
 protein coding gene Chr8:94292845-94317001 (+)
WSB/EiJ MGP_WSBEiJ_G0033107
 protein coding gene Chr8:95978276-96001544 (+)



Homology
more
  • Human Ortholog
    DRC7, dynein regulatory complex subunit 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRC7, dynein regulatory complex subunit 7
  • Synonyms
    C16orf50, CCDC135, CFAP50, FAP50
  • Links
    NCBI Gene ID: 84229
    neXtProt AC: NX_Q8IY82
    UniProt: Q8IY82

  • Chr Location
    16q21; chr16:57694793-57731805 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele are infertile with very few spermatozoa, immotile sperm, and abnormal sperm head and flagellum morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 330830 NCBI Gene Model | MGI Sequence Detail 23039 C57BL/6J ±  kb
    transcript NM_001042715 RefSeq | MGI Sequence Detail 2832 Not Specified  
    polypeptide Q6V3W6 UniProt | EBI | MGI Sequence Detail 876 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 1
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:113018 Ma Q, et al., Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells. Mol Reprod Dev. 2006 Sep;73(9):1075-83
    • Latest
      J:297362 Bachvarova V, et al., Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Nov;93:43-59
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory