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Slc9a5 Gene Detail
Summary
  • Symbol
    Slc9a5
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 5
  • Synonyms
    LOC277973
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685542
    NCBI Gene: 277973
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106075475-106096513 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685542
protein coding gene Chr8:106074782-106096513 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034042
protein coding gene Chr8:107622143-107645296 (+)
A/J MGP_AJ_G0034023
protein coding gene Chr8:103326699-103348422 (+)
AKR/J MGP_AKRJ_G0033949
protein coding gene Chr8:106310955-106336433 (+)
BALB/cJ MGP_BALBcJ_G0034016
protein coding gene Chr8:103502169-103524745 (+)
C3H/HeJ MGP_C3HHeJ_G0033728
protein coding gene Chr8:107062114-107085017 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034536
protein coding gene Chr8:111567234-111589152 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031478
protein coding gene Chr8:96475879-96497335 (+)
CAST/EiJ MGP_CASTEiJ_G0033054
protein coding gene Chr8:106558742-106580457 (+)
CBA/J MGP_CBAJ_G0033701
protein coding gene Chr8:115175588-115203735 (+)
DBA/2J MGP_DBA2J_G0033856
protein coding gene Chr8:102672051-102693601 (+)
FVB/NJ MGP_FVBNJ_G0033802
protein coding gene Chr8:101595627-101618270 (+)
LP/J MGP_LPJ_G0033947
protein coding gene Chr8:107827764-107852368 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033845
protein coding gene Chr8:118379392-118402352 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034554
protein coding gene Chr8:106288137-106311135 (+)
PWK/PhJ MGP_PWKPhJ_G0032755
protein coding gene Chr8:102059408-102081504 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032596
protein coding gene Chr8:104961904-104983476 (+)
WSB/EiJ MGP_WSBEiJ_G0033170
protein coding gene Chr8:106940412-106963062 (+)



Homology
more
  • Human Ortholog
    SLC9A5, solute carrier family 9 member A5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A5, solute carrier family 9 member A5
  • Synonyms
    NHE5
  • Links
    NCBI Gene ID: 6553
    neXtProt AC: NX_Q14940
    UniProt: Q14940

  • Chr Location
    16q22.1; chr16:67237683-67272191 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SLC9A5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced learning and memory and synapse morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014786 Ensembl Gene Model | MGI Sequence Detail 21039 C57BL/6J ±  kb
    transcript ENSMUST00000073149 Ensembl | MGI Sequence Detail 3499 Not Applicable  
    polypeptide ENSMUSP00000072893 Ensembl | MGI Sequence Detail 898 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 32
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:302075 Chen X, et al., Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice. Am J Med Genet B Neuropsychiatr Genet. 2017 Dec;174(8):828-838

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory