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Ism2 Gene Detail
Summary
  • Symbol
    Ism2
  • Name
    isthmin 2
  • Synonyms
    LOC217738, Thsd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685110
    NCBI Gene: 217738
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:87325412-87346479 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685110
 protein coding gene Chr12:87325412-87346624 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019985
 protein coding gene Chr12:88178339-88202991 (-)
A/J MGP_AJ_G0019943
 protein coding gene Chr12:84829880-84851700 (-)
AKR/J MGP_AKRJ_G0019918
 protein coding gene Chr12:87135521-87158460 (-)
BALB/cJ MGP_BALBcJ_G0019922
 protein coding gene Chr12:85162629-85183450 (-)
C3H/HeJ MGP_C3HHeJ_G0019728
 protein coding gene Chr12:87623563-87646567 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020374
 protein coding gene Chr12:90720721-90745427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017992
 protein coding gene Chr12:81709217-81731176 (-)
CAST/EiJ MGP_CASTEiJ_G0019278
 protein coding gene Chr12:82653831-82678959 (-)
CBA/J MGP_CBAJ_G0019700
 protein coding gene Chr12:94192149-94213113 (-)
DBA/2J MGP_DBA2J_G0019813
 protein coding gene Chr12:84325123-84346568 (-)
FVB/NJ MGP_FVBNJ_G0019800
 protein coding gene Chr12:83319199-83340930 (-)
LP/J MGP_LPJ_G0019887
 protein coding gene Chr12:88059263-88080227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019839
 protein coding gene Chr12:96955926-96980234 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020406
 protein coding gene Chr12:86760675-86781722 (-)
PWK/PhJ MGP_PWKPhJ_G0019042
 protein coding gene Chr12:78879304-78903437 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018837
 protein coding gene Chr12:81265982-81293890 (-)
WSB/EiJ MGP_WSBEiJ_G0019331
 protein coding gene Chr12:87538320-87559270 (-)



Homology
more
  • Human Ortholog
    ISM2, isthmin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISM2, isthmin 2
  • Synonyms
    TAIL1, THSD3
  • Links
    NCBI Gene ID: 145501
    neXtProt AC: NX_Q6H9L7
    UniProt: Q6H9L7

  • Chr Location
    14q24.3; chr14:77474394-77498816 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    1
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050671 Ensembl Gene Model | MGI Sequence Detail 21068 C57BL/6J ±  kb
transcript ENSMUST00000125733 Ensembl | MGI Sequence Detail 2526 Not Applicable  
polypeptide ENSMUSP00000117108 Ensembl | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR005533 AMOP domain
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory