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Dchs1 Gene Detail
Summary
  • Symbol
    Dchs1
  • Name
    dachsous cadherin related 1
  • Synonyms
    3110041P15Rik, C130033F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685011
    NCBI Gene: 233651
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105402197-105436861 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685011
 protein coding gene Chr7:105402196-105437562 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032765
 protein coding gene Chr7:109022261-109058342 (-)
A/J MGP_AJ_G0032745
 protein coding gene Chr7:106176330-106210804 (-)
AKR/J MGP_AKRJ_G0032678
 protein coding gene Chr7:108939507-108976235 (-)
BALB/cJ MGP_BALBcJ_G0032751
 protein coding gene Chr7:105881408-105915874 (-)
C3H/HeJ MGP_C3HHeJ_G0032460
 protein coding gene Chr7:109047076-109082227 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033256
 protein coding gene Chr7:113385871-113422085 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030240
 protein coding gene Chr7:108140061-108174587 (-)
CAST/EiJ MGP_CASTEiJ_G0031790
 protein coding gene Chr7:100877156-100913311 (-)
CBA/J MGP_CBAJ_G0032434
 protein coding gene Chr7:117157991-117193324 (-)
DBA/2J MGP_DBA2J_G0032587
 protein coding gene Chr7:104433056-104468161 (-)
FVB/NJ MGP_FVBNJ_G0032540
 protein coding gene Chr7:104241237-104278572 (-)
LP/J MGP_LPJ_G0032678
 protein coding gene Chr7:110428328-110462797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032572
 protein coding gene Chr7:118736057-118770820 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033277
 protein coding gene Chr7:108013499-108048446 (-)
PWK/PhJ MGP_PWKPhJ_G0031503
 protein coding gene Chr7:97374285-97411741 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031352
 protein coding gene Chr7:95121647-95157404 (-)
WSB/EiJ MGP_WSBEiJ_G0031907
 protein coding gene Chr7:108649580-108684946 (-)



Homology
more
  • Human Ortholog
    DCHS1, dachsous cadherin-related 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCHS1, dachsous cadherin-related 1
  • Synonyms
    CDH19, CDH25, CDHR6, FIB1, MMVP2, MVP2, PCDH16, VMLDS1
  • Links
    NCBI Gene ID: 8642
    neXtProt AC: NX_Q96JQ0
    UniProt: Q96JQ0

  • Chr Location
    11p15.4; chr11:6621330-6655809 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dchs1 mouse models; 2 with human DCHS1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    39
  • cDNA Data
    106
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036862 Ensembl Gene Model | MGI Sequence Detail 34665 C57BL/6J ±  kb
    transcript ENSMUST00000078482 Ensembl | MGI Sequence Detail 10754 Not Applicable  
    polypeptide ENSMUSP00000077574 Ensembl | MGI Sequence Detail 3291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 106
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920409
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:327314 Moore KS, et al., DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse. J Cardiovasc Dev Dis. 2022 Feb 17;9(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory