Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp3tm1Kin
Name:	caspase 3; targeted mutation 1, Ken-Ichi Nakayama
MGI ID:	MGI:2684608
Synonyms:	caspase-3 -
Gene:	Casp3  Location: Chr8:47070326-47092724 bp, + strand  Genetic Position: Chr8, 26.39 cM
Alliance:	Casp3tm1Kin page

Germline Transmission:	Earliest citation of germline transmission: J:69809
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a 9.8 kb genomic fragment containing sequences encoding the QACRG motif of the catalytic site of the encoded protien. RT-PCR and immunohistochemistry experiments confirmed that no detectable transcript and protein was made from this allele. (J:69809)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp3 Mutation:	31 strains or lines available

Original:	J:69809 Morishita H, et al., Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun. 2001 Jun 1;284(1):142-9
All:	1 reference(s)