Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sp8tm1Smb
Name:	trans-acting transcription factor 8; targeted mutation 1, Sheila M Bell
MGI ID:	MGI:2684070
Synonyms:	Sp8-
Gene:	Sp8  Location: Chr12:118810064-118816311 bp, + strand  Genetic Position: Chr12, 63.48 cM
Alliance:	Sp8tm1Smb page

Germline Transmission:	Earliest citation of germline transmission: J:86196
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The majority of the coding region, including the zinc finger domain, was deleted via cre mediated recombination of loxP sites in intron 2 and in the 3' untranslated region. (J:86196)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	110 assay results
In Structures Affected by this Mutation:	34 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp8 Mutation:	29 strains or lines available

Original:	J:86196 Bell SM, et al., Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12195-200
All:	9 reference(s)