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Ttc5 Gene Detail
Summary
  • Symbol
    Ttc5
  • Name
    tetratricopeptide repeat domain 5
  • Synonyms
    MGC:38092
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683584
    NCBI Gene: 219022
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51002872-51022976 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683584
 protein coding gene Chr14:51002866-51022977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021256
 protein coding gene Chr14:44709398-44730821 (-)
A/J MGP_AJ_G0021210
 protein coding gene Chr14:43376684-43397347 (-)
AKR/J MGP_AKRJ_G0021186
 protein coding gene Chr14:45006495-45026589 (-)
BALB/cJ MGP_BALBcJ_G0021213
 protein coding gene Chr14:43490713-43511115 (-)
C3H/HeJ MGP_C3HHeJ_G0020995
 protein coding gene Chr14:44826878-44851478 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021649
 protein coding gene Chr14:46525756-46545877 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019202
 protein coding gene Chr14:42716943-42737749 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0020962
 protein coding gene Chr14:48009090-48034290 (-)
DBA/2J MGP_DBA2J_G0021086
 protein coding gene Chr14:43272410-43293584 (-)
FVB/NJ MGP_FVBNJ_G0021067
 protein coding gene Chr14:42900007-42920284 (-)
LP/J MGP_LPJ_G0021154
 protein coding gene Chr14:44989486-45012475 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021095
 protein coding gene Chr14:47490897-47517641 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021679
 protein coding gene Chr14:44499232-44519807 (-)
PWK/PhJ MGP_PWKPhJ_G0020269
 protein coding gene Chr14:40171083-40191888 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020094
 protein coding gene Chr14:40659015-40680381 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TTC5, tetratricopeptide repeat domain 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC5, tetratricopeptide repeat domain 5
  • Synonyms
    NEDCAFD, Strap
  • Links
    NCBI Gene ID: 91875
    neXtProt AC: NX_Q8N0Z6
    UniProt: Q8N0Z6

  • Chr Location
    14q11.2; chr14:20256558-20305960 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    53
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006288 Ensembl Gene Model | MGI Sequence Detail 20105 C57BL/6J ±  kb
transcript ENSMUST00000006451 Ensembl | MGI Sequence Detail 1842 Not Applicable  
polypeptide ENSMUSP00000006451 Ensembl | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145844
References
more
  • Summaries
    All 39
    Gene Ontology 13
    Phenotypes 9
  • Earliest
    J:314962 Demonacos C, et al., A TPR motif cofactor contributes to p300 activity in the p53 response. Mol Cell. 2001 Jul;8(1):71-84
  • Latest
    J:314387 Hu X, et al., LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. J Cell Biol. 2019 Jan 7;218(1):251-266
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory