Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdk5r1tm1Ivi
Name:	cyclin dependent kinase 5, regulatory subunit 1; targeted mutation 1, Inez Vincent
MGI ID:	MGI:2683302
Synonyms:	p35-
Gene:	Cdk5r1  Location: Chr11:80367849-80372010 bp, + strand  Genetic Position: Chr11, 47.94 cM
Alliance:	Cdk5r1tm1Ivi page

Germline Transmission:	Earliest citation of germline transmission: J:86345
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.5 kb fragment of the gene containing all of the coding region was replaced with a neomycin resistance cassette in reverse orientation. Protein product was undetectable in homozygotes by Western blot analysis. (J:86345)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk5r1 Mutation:	13 strains or lines available

Original:	J:86345 Hallows JL, et al., Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci. 2003 Nov 19;23(33):10633-44
All:	10 reference(s)