Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sncgtm1Vlb
Name:	synuclein, gamma; targeted mutation 1, Vladimir L Buchman
MGI ID:	MGI:2683142
Synonyms:	TgHSNCGtm1VLB
Gene:	Sncg  Location: Chr14:34092231-34096626 bp, - strand  Genetic Position: Chr14, 20.81 cM, cytoband B-C
Alliance:	Sncgtm1Vlb page

Germline Transmission:	Earliest citation of germline transmission: J:86439
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 through 3 were replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from various tissues. Western blot analysis of total spinal cord protein indicated an absence of protein in homozygous mutant mice. (J:86439)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sncg Mutation:	14 strains or lines available

Original:	J:86439 Ninkina N, et al., Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene. Mol Cell Biol. 2003 Nov;23(22):8233-45
All:	18 reference(s)