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Dnah3 Gene Detail
Summary
  • Symbol
    Dnah3
  • Name
    dynein, axonemal, heavy chain 3
  • Synonyms
    Dnahc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683040
    NCBI Gene: 381917
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:119521894-119694503 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    970 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683040
 protein coding gene Chr7:119520555-119694520 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032922
 protein coding gene Chr7:123860832-124037538 (-)
A/J MGP_AJ_G0032905
 protein coding gene Chr7:120653492-120829754 (-)
AKR/J MGP_AKRJ_G0032837
 protein coding gene Chr7:123769152-123945809 (-)
BALB/cJ MGP_BALBcJ_G0032910
 protein coding gene Chr7:120386351-120557813 (-)
C3H/HeJ MGP_C3HHeJ_G0032620
 protein coding gene Chr7:123674581-123851095 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033416
 protein coding gene Chr7:128756828-128945436 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030388
 protein coding gene Chr7:122083801-122247494 (-)
CAST/EiJ MGP_CASTEiJ_G0031948
 protein coding gene Chr7:115429397-115606818 (-)
CBA/J MGP_CBAJ_G0032593
 protein coding gene Chr7:133055287-133251325 (-)
DBA/2J MGP_DBA2J_G0032745
 protein coding gene Chr7:118702199-118875415 (-)
FVB/NJ MGP_FVBNJ_G0032698
 protein coding gene Chr7:118541695-118707940 (-)
LP/J MGP_LPJ_G0032839
 protein coding gene Chr7:125313405-125493972 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032730
 protein coding gene Chr7:134516046-134703564 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033436
 protein coding gene Chr7:122743439-122926764 (-)
PWK/PhJ MGP_PWKPhJ_G0031656
 protein coding gene Chr7:111620819-111793988 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031502
 protein coding gene Chr7:109497523-109675804 (-)
WSB/EiJ MGP_WSBEiJ_G0032061
 protein coding gene Chr7:123648093-123825037 (-)



Homology
more
  • Human Ortholog
    DNAH3, dynein axonemal heavy chain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH3, dynein axonemal heavy chain 3
  • Synonyms
    DNAHC3B, DNAHC3-B, HDHC8, HEL-36, HSADHC3
  • Links
    NCBI Gene ID: 55567
    neXtProt AC: NX_Q8TD57
    UniProt: Q8TD57

  • Chr Location
    16p12.3; chr16:20933111-21159459 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052273 Ensembl Gene Model | MGI Sequence Detail 172610 C57BL/6J ±  kb
transcript ENSMUST00000046993 Ensembl | MGI Sequence Detail 12252 Not Applicable  
polypeptide ENSMUSP00000042857 Ensembl | MGI Sequence Detail 4083 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006563 dynein axonemal heavy chain 3
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR026983 Dynein heavy chain
    IPR041589 Dynein heavy chain 3, AAA+ lid domain
    IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
    IPR041466 Dynein heavy chain, AAA 5 extension domain
    IPR041658 Dynein heavy chain AAA lid domain
    IPR042219 Dynein heavy chain AAA lid domain superfamily
    IPR024317 Dynein heavy chain, AAA module D4
    IPR035706 Dynein heavy chain, ATP-binding dynein motor region
    IPR024743 Dynein heavy chain, coiled coil stalk
    IPR041228 Dynein heavy chain, C-terminal domain
    IPR043160 Dynein heavy chain, C-terminal domain, barrel region
    IPR042222 Dynein heavy chain, domain 2, N-terminal
    IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
    IPR013602 Dynein heavy chain, linker
    IPR042228 Dynein heavy chain, linker, subdomain 3
    IPR004273 Dynein heavy chain region D6 P-loop domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 4
    Genomic 2
    cDNA 2

    Microarray probesets 6
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:43700 Neesen J, et al., Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Gene. 1997 Oct 24;200(1-2):193-202
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory