Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Icmttm1Sgy
Name:	isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Stephen G Young
MGI ID:	MGI:2680650
Synonyms:	Icmt -
Gene:	Icmt  Location: Chr4:152381684-152391578 bp, + strand  Genetic Position: Chr4, 83.02 cM
Alliance:	Icmttm1Sgy page

Germline Transmission:	Earliest citation of germline transmission: J:67598
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 1 through homologous recombination. Activity of the encoded protein was shown to be abolished in homozygous ES cells. (J:62754)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icmt Mutation:	11 strains or lines available

Original:	J:67598 Bergo MO, et al., Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem. 2001 Feb 23;276(8):5841-5
All:	4 reference(s)