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Vsig4 Gene Detail
Summary
  • Symbol
    Vsig4
  • Name
    V-set and immunoglobulin domain containing 4
  • Synonyms
    CRIg, MGC:36211, Z39IG
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679720
    NCBI Gene: 278180
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:95290809-95337044 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679720
 protein coding gene ChrX:95290807-95337044 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035924
 protein coding gene ChrX:92629864-92680103 (-)
A/J MGP_AJ_G0035910
 protein coding gene ChrX:92788958-92821378 (-)
AKR/J MGP_AKRJ_G0035826
 protein coding gene ChrX:95285165-95321731 (-)
BALB/cJ MGP_BALBcJ_G0035893
 protein coding gene ChrX:91540547-91577934 (-)
C3H/HeJ MGP_C3HHeJ_G0035601
 protein coding gene ChrX:93116543-93152296 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036422
 protein coding gene ChrX:95554295-95597847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033251
 protein coding gene ChrX:90787606-90812385 (-)
CAST/EiJ MGP_CASTEiJ_G0034888
 protein coding gene ChrX:77622504-77648195 (-)
CBA/J MGP_CBAJ_G0035577
 protein coding gene ChrX:98458805-98493391 (-)
DBA/2J MGP_DBA2J_G0035731
 protein coding gene ChrX:91989971-92034308 (-)
FVB/NJ MGP_FVBNJ_G0035669
 protein coding gene ChrX:91397546-91441409 (-)
LP/J MGP_LPJ_G0035821
 protein coding gene ChrX:93633234-93662111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035704
 protein coding gene ChrX:102717421-102753911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036449
 protein coding gene ChrX:92361219-92398654 (-)
PWK/PhJ MGP_PWKPhJ_G0034587
 protein coding gene ChrX:75269677-75320158 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034416
 protein coding gene ChrX:78451423-78486855 (-)
WSB/EiJ MGP_WSBEiJ_G0035027
 protein coding gene ChrX:91196721-91236924 (-)



Homology
more
  • Human Ortholog
    VSIG4, V-set and immunoglobulin domain containing 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VSIG4, V-set and immunoglobulin domain containing 4
  • Synonyms
    CRIg, Z39IG
  • Links
    NCBI Gene ID: 11326
    neXtProt AC: NX_Q9Y279
    UniProt: Q9Y279

  • Chr Location
    Xq12; chrX:66021738-66040125 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to exhibit complement-dependent clearance of Staphylococcus aureus from the circulation and are more susceptible to Listeria monocytogenes infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044206 Ensembl Gene Model | MGI Sequence Detail 46236 C57BL/6J ±  kb
    transcript ENSMUST00000050707 Ensembl | MGI Sequence Detail 1432 Not Applicable  
    polypeptide ENSMUSP00000051521 Ensembl | MGI Sequence Detail 280 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 25
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:335481 Liu W, et al., In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis. J Clin Invest. 2023 Apr 17;133(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory