Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Pak4tm1Amin
Name:	p21 (RAC1) activated kinase 4; targeted mutation 1, Audrey Minden
MGI ID:	MGI:2679635
Synonyms:	PAK4-
Gene:	Pak4  Location: Chr7:28258244-28297609 bp, - strand  Genetic Position: Chr7, 16.84 cM
Alliance:	Pak4tm1Amin page

Germline Transmission:	Earliest citation of germline transmission: J:85954
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1, containing the initiating methionine and the critical GTPase-binding domaain, was replaced with a PGK-neo cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analysis of homozygous mutant brain tissue. (J:85954)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pak4 Mutation:	91 strains or lines available

Original:	J:85954 Qu J, et al., PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct;23(20):7122-33
All:	3 reference(s)