Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cplx1tm2Bros
Name:	complexin 1; targeted mutation 2, Nils Brose
MGI ID:	MGI:2679624
Synonyms:	Cplx1-, Cplx1tm1Rmnd, CPX I-
Gene:	Cplx1  Location: Chr5:108666420-108697890 bp, - strand  Genetic Position: Chr5, 53.17 cM
Alliance:	Cplx1tm2Bros page

Germline Transmission:	Earliest citation of germline transmission: J:86365
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first coding exon was replaced by a neomycin resistance gene. Western blot analysis of adult brains demonstrated the abolition of protein product expression. (J:86365)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cplx1 Mutation:	13 strains or lines available

Original:	J:86365 Reim K, et al., Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell. 2001 Jan 12;104(1):71-81
All:	18 reference(s)