About   Help   FAQ
Ptprqtm1Bow
Targeted Allele Detail
Summary
Symbol: Ptprqtm1Bow
Name: protein tyrosine phosphatase receptor type Q; targeted mutation 1, Daniel F Bowen-Pope
MGI ID: MGI:2679315
Synonyms: Ptprq-TM-KO
Gene: Ptprq  Location: Chr10:107352910-107555912 bp, - strand  Genetic Position: Chr10, 55.97 cM
Alliance: Ptprqtm1Bow page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85926
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette inserted by homologous recombination replaced a 2396 bp fragment containing the exon encoding the transmembrane domain and flanking intronic sequence. While, mutant transcript lacking the targeted fragment was detected by RT-PCR analysis of cochlear RNA obtained from homozygous mutant mice, protein was undetected by immunostaining. (J:85926)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprq Mutation:  133 strains or lines available
References
Original:  J:85926 Goodyear RJ, et al., A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. J Neurosci. 2003 Oct 8;23(27):9208-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory