Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Terf1tm1Tdl
Name:	telomeric repeat binding factor 1; targeted mutation 1, Titia de Lange
MGI ID:	MGI:2677837
Synonyms:	Terfex1delta
Gene:	Terf1  Location: Chr1:15875870-15914276 bp, + strand  Genetic Position: Chr1, 4.88 cM, cytoband E3
Alliance:	Terf1tm1Tdl page

Germline Transmission:	Earliest citation of germline transmission: J:85440
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced by a neomycin resistance gene. Northern blot analysis of RNA purified from heterozygotes indicated only about half of the normal amount of mRNA transcript was present. No truncated mRNA species were observed. (J:85440)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Terf1 Mutation:	35 strains or lines available

Original:	J:85440 Karlseder J, et al., Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol. 2003 Sep;23(18):6533-41
All:	4 reference(s)