Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mrc2tm1Bug
Name:	mannose receptor, C type 2; targeted mutation 1, Thomas H Bugge
MGI ID:	MGI:2677819
Synonyms:	uPARAP/Endo180 -
Gene:	Mrc2  Location: Chr11:105183469-105241965 bp, + strand  Genetic Position: Chr11, 68.73 cM, cytoband E1
Alliance:	Mrc2tm1Bug page

Germline Transmission:	Earliest citation of germline transmission: J:82737
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An HPRT expression cassette replaced a genomic fragment containing exons 2-6. A truncated transcript is expressed from this allele, but no full length protein was detected by western blot on lysates of dermal fibroblasts derived from homozygous mice. (J:82737)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

53 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mrc2 Mutation:	119 strains or lines available

Original:	J:82737 Engelholm LH, et al., uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol. 2003 Mar 31;160(7):1009-15
All:	16 reference(s)