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Sh2d2atm1Jbs
Targeted Allele Detail
Summary
Symbol: Sh2d2atm1Jbs
Name: SH2 domain containing 2A; targeted mutation 1, Jeffrey Bluestone
MGI ID: MGI:2676915
Synonyms: RIBP KO, TSAd-
Gene: Sh2d2a  Location: Chr3:87754062-87763029 bp, + strand  Genetic Position: Chr3, 38.78 cM
Alliance: Sh2d2atm1Jbs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64938
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4, which encode the SH2 domain, were replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of activated splenocytes obtained from homozygous mutant mice. (J:64938)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d2a Mutation:  18 strains or lines available
References
Original:  J:64938 Rajagopal K, et al., RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 1999 Dec 6;190(11):1657-68
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory