Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pde1btm1Cvv
Name:	phosphodiesterase 1B, Ca2+-calmodulin dependent; targeted mutation 1, Charles V Vorhees
MGI ID:	MGI:2676625
Synonyms:	PDE1B-
Gene:	Pde1b  Location: Chr15:103411461-103438479 bp, + strand  Genetic Position: Chr15, 58.99 cM
Alliance:	Pde1btm1Cvv page

Germline Transmission:	Earliest citation of germline transmission: J:77514
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 6 through 9 have been replaced with a PGK-HPRT cassette disrupting sequences encoding the catalytic domain. Northern blot analysis demonstrated that mRNA transcripts of this allele were not present in RNA extracted from brains of homozygotes. (J:77514)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde1b Mutation:	49 strains or lines available

Original:	J:77514 Reed TM, et al., Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J Neurosci. 2002 Jun 15;22(12):5188-97
All:	2 reference(s)