Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Syt7tm1Nan Name: synaptotagmin VII; targeted mutation 1, Norma W Andrews MGI ID: MGI:2676220 Synonyms: Syt VII - Gene: Syt7  Location: Chr19:10366454-10430544 bp, + strand  Genetic Position: Chr19, 6.58 cM, cytoband B Alliance: Syt7tm1Nan page

Inflammation, injury and fibrosis in skin and skeletal muscle of Syt7tm1Nan/Syt7tm1Nan mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:85201
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP flanked neomycin resistance cassette replaced most of exon 4 and exon 5. In the process a stop codon was generated in exon 4 after the codon for amino acid 83. Absence of the 1.2kb mRNA for the major isoform of this gene was established by Northern blot analysis. Lack of protein product was confirmed by Western blot analysis. However, a truncated protein may be produced. (J:85201)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syt7 Mutation:	38 strains or lines available

Original:	J:85201 Chakrabarti S, et al., Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003 Aug 18;162(4):543-9
All:	22 reference(s)