Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gas6tm1Pec
Name:	growth arrest specific 6; targeted mutation 1, Peter Carmeliet
MGI ID:	MGI:2675495
Synonyms:	Gas6-
Gene:	Gas6  Location: Chr8:13515374-13544490 bp, - strand  Genetic Position: Chr8, 6.06 cM
Alliance:	Gas6tm1Pec page

Germline Transmission:	Earliest citation of germline transmission: J:77462
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Sequences encoding the transcription start site, the start codon, the signal peptide, and the Gla module which is required for binding of the endogenous protein to phospholipid membranes were deleted. Normal transcript was undetected by Northern blot analysis of MEFs derived from homozygous mutant mice, while normal protein was shown to be absent from homozygous mutant kidney extracts by Western blot analysis using an antibody directed against the C-terminal. (J:77462)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gas6 Mutation:	36 strains or lines available

Original:	J:77462 Angelillo-Scherrer A, et al., Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001 Feb;7(2):215-21
All:	33 reference(s)