Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itga2tm1.1Eck
Name:	integrin alpha 2; targeted mutation 1.1, Beate Eckes
MGI ID:	MGI:2675420
Synonyms:	alpha2(-)
Gene:	Itga2  Location: Chr13:114969617-115068636 bp, - strand  Genetic Position: Chr13, 64.61 cM
Alliance:	Itga2tm1.1Eck page

Germline Transmission:	Earliest citation of germline transmission: J:75683
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed region including exon 1 was excised from Itga2tm1Eck via cre-mediated recombination. Protein was undetected in homozygous mutant mice by Western blot anlaysis of lung and spleen tissue and platelets. (J:75683)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga2 Mutation:	79 strains or lines available

Original:	J:75683 Holtkotter O, et al., Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem. 2002 Mar 29;277(13):10789-94
All:	10 reference(s)