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Sigirrtm1Lix
Targeted Allele Detail
Summary
Symbol: Sigirrtm1Lix
Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; targeted mutation 1, Xiaoxia Li
MGI ID: MGI:2675236
Synonyms: Sigirr-
Gene: Sigirr  Location: Chr7:140671088-140680485 bp, - strand  Genetic Position: Chr7, 86.35 cM
Alliance: Sigirrtm1Lix page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85151
Parent Cell Line:  MC50 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The insertion of neo was reported to generate stop codons in all three reading frames. Endogenous transcript was undetected by Northern blot analysis of homozygous mutant kidney tissue. (J:85151)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sigirr Mutation:  28 strains or lines available
References
Original:  J:85151 Wald D, et al., SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003 Sep;4(9):920-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory