Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pgrtm2Omc
Name:	progesterone receptor; targeted mutation 2, Orla M Conneely
MGI ID:	MGI:2674932
Synonyms:	PRBKO-
Gene:	Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance:	Pgrtm2Omc page

Germline Transmission:	Earliest citation of germline transmission: J:85196
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: To eliminate the translation of isoform B, the start codon of isoform B was mutated to encode leucine (ATG to CTG). A single loxP site remained in an intron after a floxed selection cassette was excised via cre mediated recombination. While isoform B was undetected by Western blot analysis of homozygous mutant uterine extracts, the presence of isoform A was confirmed. (J:85196)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:	73 strains or lines available

Original:	J:85196 Mulac-Jericevic B, et al., Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9744-9
All:	7 reference(s)