Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlr2tm1Kir
Name:	toll-like receptor 2; targeted mutation 1, Carsten J Kirschning
MGI ID:	MGI:2674036
Synonyms:	Ly105, TLR2-
Gene:	Tlr2  Location: Chr3:83743579-83749045 bp, - strand  Genetic Position: Chr3, 37.4 cM
Alliance:	Tlr2tm1Kir page

Germline Transmission:	Earliest citation of germline transmission: J:85323
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding the extracellular domain and a portion of the transmembrane domain was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of peritoneal macrophages obtained from homozygous mutant mice. (J:85323, J:130011)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tlr2 Mutation:	56 strains or lines available

Original:	J:85323 Wooten RM, et al., Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol. 2002 Jan 1;168(1):348-55
All:	372 reference(s)