Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map2k6tm1Flv
Name:	mitogen-activated protein kinase kinase 6; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:2673716
Synonyms:	Mkk6-
Gene:	Map2k6  Location: Chr11:110289948-110416348 bp, + strand  Genetic Position: Chr11, 73.6 cM, cytoband E1
Alliance:	Map2k6tm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:85266
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo cassette inserted by homologous recombination replaced the exon encoding subdomain XI which is essential for catalytic activity. Protein was undetected by Western blot analaysis of splenocytes obtained from homozygous mutant mice. (J:85266)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map2k6 Mutation:	42 strains or lines available

Original:	J:85266 Tanaka N, et al., Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 2002 Aug;3(8):785-91
All:	15 reference(s)