Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Btrctm1Kin
Name:	beta-transducin repeat containing protein; targeted mutation 1, Kei-ichi Nakayama
MGI ID:	MGI:2669949
Synonyms:	Beta-TrCP1-
Gene:	Btrc  Location: Chr19:45352173-45518452 bp, + strand  Genetic Position: Chr19, 38.75 cM, cytoband D1
Alliance:	Btrctm1Kin page

Germline Transmission:	Earliest citation of germline transmission: J:84639
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of RNA isolated from the testes of homozygous mutant mice. (J:84639)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btrc Mutation:	47 strains or lines available

Original:	J:84639 Nakayama K, et al., Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8752-7
All:	6 reference(s)