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Tmc3 Gene Detail
Summary
  • Symbol
    Tmc3
  • Name
    transmembrane channel-like gene family 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669033
    NCBI Gene: 233424
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:83234135-83274822 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 47.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669033
 protein coding gene Chr7:83234112-83276060 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032449
 protein coding gene Chr7:85745451-85789157 (+)
A/J MGP_AJ_G0032427
 protein coding gene Chr7:83671592-83714882 (+)
AKR/J MGP_AKRJ_G0032363
 protein coding gene Chr7:85595030-85638749 (+)
BALB/cJ MGP_BALBcJ_G0032439
 protein coding gene Chr7:83350440-83391407 (+)
C3H/HeJ MGP_C3HHeJ_G0032153
 protein coding gene Chr7:86148447-86189101 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032930
 protein coding gene Chr7:89065864-89107553 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029939
 protein coding gene Chr7:86050231-86091587 (+)
CAST/EiJ MGP_CASTEiJ_G0031480
 protein coding gene Chr7:77110726-77156739 (+)
CBA/J MGP_CBAJ_G0032118
 protein coding gene Chr7:92050450-92096453 (+)
DBA/2J MGP_DBA2J_G0032273
 protein coding gene Chr7:82178364-82218979 (+)
FVB/NJ MGP_FVBNJ_G0032227
 protein coding gene Chr7:82131627-82172403 (+)
LP/J MGP_LPJ_G0032354
 protein coding gene Chr7:86989145-87029788 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032264
 protein coding gene Chr7:92076717-92124464 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032950
 protein coding gene Chr7:84990442-85031948 (+)
PWK/PhJ MGP_PWKPhJ_G0031200
 protein coding gene Chr7:75410326-75452437 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031042
 protein coding gene Chr7:71972088-72026359 (+)
WSB/EiJ MGP_WSBEiJ_G0031597
 protein coding gene Chr7:85365097-85405744 (+)



Homology
more
  • Human Ortholog
    TMC3, transmembrane channel like 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMC3, transmembrane channel like 3
  • Links
    NCBI Gene ID: 342125
    neXtProt AC: NX_Q7Z5M5
    UniProt: Q7Z5M5

  • Chr Location
    15q25.1; chr15:81331088-81374213 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038540 Ensembl Gene Model | MGI Sequence Detail 40688 C57BL/6J ±  kb
transcript ENSMUST00000039317 Ensembl | MGI Sequence Detail 6221 Not Applicable  
polypeptide ENSMUSP00000046028 Ensembl | MGI Sequence Detail 1130 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory