Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfsf14tm1Ddy
Name:	tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Derek D Yang
MGI ID:	MGI:2668383
Synonyms:	LIGHT-
Gene:	Tnfsf14  Location: Chr17:57496492-57501177 bp, - strand  Genetic Position: Chr17, 29.71 cM, cytoband D-E1
Alliance:	Tnfsf14tm1Ddy page

Germline Transmission:	Earliest citation of germline transmission: J:84366
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-3, which encode amino acids 1-98, were replaced with a PGK-neomycin cassette. Absence of mRNA was established by Northern blot analysis of RNA isolated from spleens of homozygotes. (J:84366)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf14 Mutation:	25 strains or lines available

Original:	J:84366 Liu J, et al., LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function. Int Immunol. 2003 Jul;15(7):861-70
All:	1 reference(s)