Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Map2k2tm1Chrn
Name:	mitogen-activated protein kinase kinase 2; targeted mutation 1, Jean Charron
MGI ID:	MGI:2668345
Synonyms:	MEK2-
Gene:	Map2k2  Location: Chr10:80941749-80960531 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Map2k2tm1Chrn page

Germline Transmission:	Earliest citation of germline transmission: J:84382
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced sequences from exons 4, 5, and 6. This results in the loss of kinase subdomains VII and VIII. Western blot analysis of protein extracts from E11.5 embryos indicated that both full length and truncated protein were absent. (J:84382)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

14 assay results 5 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Map2k2tm1Chrn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map2k2 Mutation:	35 strains or lines available

Original:	J:84382 Belanger LF, et al., Mek2 is dispensable for mouse growth and development. Mol Cell Biol. 2003 Jul;23(14):4778-87
All:	34 reference(s)