Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Hivep3tm1Lcw
Name:	human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 1, Lai-Chu Wu
MGI ID:	MGI:2667235
Synonyms:	KRC-
Gene:	Hivep3  Location: Chr4:119590982-119992608 bp, + strand  Genetic Position: Chr4, 55.51 cM, cytoband D1
Alliance:	Hivep3tm1Lcw page

Germline Transmission:	Earliest citation of germline transmission: J:266689
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 486 bp fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region corresponded to nucleotides 954 through 1440 of the cDNA and encoded the first zinc finger pairs. The insertion of the cassette was reported to disrupt the open reading frame at codon 99. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:79652)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Hivep3tm1Lcw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hivep3 Mutation:	103 strains or lines available

Original:	J:79652 Allen CE, et al., Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC. Genes Chromosomes Cancer. 2002 Dec;35(4):287-98
All:	3 reference(s)