Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plcd1tm1Tta
Name:	phospholipase C, delta 1; targeted mutation 1, Tadaomi Takenawa
MGI ID:	MGI:2667234
Synonyms:	PLCdelta-deficient, PLCgamma1-
Gene:	Plcd1  Location: Chr9:118900595-118922570 bp, - strand  Genetic Position: Chr9, 71.32 cM
Alliance:	Plcd1tm1Tta page

Germline Transmission:	Earliest citation of germline transmission: J:83948
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The sequences encoding the X and Y (catalytic) domains were replaced with a neomycin resistance cassette. Western blot analysis of testes proteins from homozygotes indicated the absence of gene product. Use of antibodies specific for the N-terminal 60 amino acids confirmed that no product was present. (J:83948)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcd1 Mutation:	44 strains or lines available

Original:	J:83948 Nakamura Y, et al., Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J. 2003 Jun 16;22(12):2981-91
All:	13 reference(s)