Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aldh1a1tm1Gdu
Name:	aldehyde dehydrogenase family 1, subfamily A1; targeted mutation 1, Gregg Duester
MGI ID:	MGI:2667220
Synonyms:	Raldh1-
Gene:	Aldh1a1  Location: Chr19:20470079-20620829 bp, + strand  Genetic Position: Chr19, 13.91 cM
Alliance:	Aldh1a1tm1Gdu page

Germline Transmission:	Earliest citation of germline transmission: J:83957
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 11 was replaced by a PGK-neomycin gene. This results in eliminating the region containing the substrate binding pocket and the tetramerization domain in any mRNA that might be transcribed. Resulting mice were genotyped by Southern blots. Absence of protein product was established by Western blot analysis. (J:83957)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aldh1a1 Mutation:	37 strains or lines available

Original:	J:83957 Fan X, et al., Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol. 2003 Jul;23(13):4637-48
All:	33 reference(s)