Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Btctm1Dcl
Name:	betacellulin, epidermal growth factor family member; targeted mutation 1, David C Lee
MGI ID:	MGI:2665044
Synonyms:	Btc-
Gene:	Btc  Location: Chr5:91505120-91550853 bp, - strand  Genetic Position: Chr5, 44.78 cM
Alliance:	Btctm1Dcl page

Germline Transmission:	Earliest citation of germline transmission: J:83820
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: PGK-Neo replaced exon 3 which encodes for the first two loops of EGF-like sequence that are critical for receptor binding. Northern blots confirmed the absence of gene transcripts. (J:83820)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Btc Mutation:	17 strains or lines available

Original:	J:83820 Jackson LF, et al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 2003 Jun 2;22(11):2704-16
All:	4 reference(s)