Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klf4tm1.1Khk
Name:	Kruppel-like transcription factor 4 (gut); targeted mutation 1.1, Klaus H Kaestner
MGI ID:	MGI:2664975
Synonyms:	Klf4-
Gene:	Klf4  Location: Chr4:55527143-55532466 bp, - strand  Genetic Position: Chr4, 29.76 cM
Alliance:	Klf4tm1.1Khk page

Germline Transmission:	Earliest citation of germline transmission: J:76493
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed region encompassing exons 2 and 3 was excised from Klf4tm1Khk via cre-mediated recombination in the germline. Absence of gene expression was confirmed by in situ hybridization of colon sections. (J:76493)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf4 Mutation:	24 strains or lines available

Original:	J:76493 Katz JP, et al., The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002 Jun;129(11):2619-28
All:	8 reference(s)