Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fcgr1tm1Jsv
Name:	Fc receptor, IgG, high affinity I; targeted mutation 1, J Sjef Verbeek
MGI ID:	MGI:2664927
Synonyms:	FcgammaRI-, Fcgr1tm1Sjv
Gene:	Fcgr1  Location: Chr3:96190225-96201285 bp, - strand  Genetic Position: Chr3, 41.72 cM
Alliance:	Fcgr1tm1Jsv page

Germline Transmission:	Earliest citation of germline transmission: J:83995
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 3' part of the promoter, the exons encoding the L1 and L2 domains, and the 5' portion of the exon encoding the EC domain were deleted and replaced with a hygromycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of RNA from neutrophils, macrophages, and dendritic cells. (J:83995)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Fcgr1 Mutation:	34 strains or lines available

Original:	J:83995 Ioan-Facsinay A, et al., FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity. 2002 Mar;16(3):391-402
All:	52 reference(s)