Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Carm1tm1Mtb
Name:	coactivator-associated arginine methyltransferase 1; targeted mutation 1, Mark T Bedford
MGI ID:	MGI:2663959
Synonyms:	Carm1-
Gene:	Carm1  Location: Chr9:21458163-21500763 bp, + strand  Genetic Position: Chr9, Syntenic
Alliance:	Carm1tm1Mtb page

Germline Transmission:	Earliest citation of germline transmission: J:83623
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutation:    Insertion   Mutation details: An FRT site flanked neomycin resisatnce gene cassette was inserted upstream of two exons encoding a portion of the cofactor binding domain (amino acids 117-187). Additionally, the inserted neo cassette and the two exons were flanked by a single loxP sites. Protein was undetected in homozygous mutant mice. (J:83623)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	23 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Carm1 Mutation:	93 strains or lines available

Original:	J:83623 Yadav N, et al., Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6464-8
All:	11 reference(s)